OpenBuilds BLOX can be used with any existing ESP32-S3 supported firmware development toolchains and distributions you are already skilled in as well
Below just an handful of the popular ones:
ESP-IDF (Espressif IoT Development Framework)
PlatformIO
Zephyr RTOS
Tasmota
CircuitPython
Lua (NodeMCU)
MicroPython
Blynk
Espruino
NuttX